MAASTY is a methacrylic acid–styrene copolymer series engineered for direct extraction of membrane proteins into native nanodiscs. Developed at DTU Health Tech and published in Nature Communications, RadPoly makes MAASTY available to researchers worldwide — at a price that makes screening accessible.
MAASTY40 through MAASTY60 span 40–60 mol% methacrylic acid in 5 mol% steps — giving you systematic control over hydrophilic–hydrophobic balance and the ability to find the optimal variant for your membrane protein and lipid system.
Synthesised by reversible addition-fragmentation chain-transfer polymerisation, every MAASTY batch delivers defined molecular weight and verified composition — the same reproducibility your assays demand.
MAASTY nanodiscs retain endogenous lipids — including cholesterol and phosphatidylinositol — giving you a lipid environment that reflects the native membrane rather than a reconstituted approximation.
MAASTY was developed in the Nanosmithery at DTU Health Tech. The polymer series is described in Pugh, Feilen, Autzen et al., Nature Communications 2025, where it enabled a 3.5 Å cryo-EM structure of human TRPM4 directly from native membranes. Made by the scientists who know the chemistry.